反应详情

To a solution of 2-(bromomethyl)-5-(trifluoromethyl)pyridine (3.0 g, 12.5 mmol) in toluene (100 ml) was added triethyl phosphite (6.2 g, 37.0 mmol). The reaction was refluxed for 17 hours and was then concentrated in vacuo. The resulting residue was purified by column chromatography (silica, 0-50% ethyl acetate/n-hexane) to afford the title compound.

1. temperatureThe reaction was refluxed for 17 hours
2. concentrationwas then concentrated in vacuo
3. customThe resulting residue was purified by column chromatography (silica, 0-50% ethyl acetate/n-hexane)