Triethyl phosphite → Diethyl ((5-(trifluoromethyl)pyridin-2-yl)methyl)phosphonate

HRID 1750532노트

반응식

HRID 1750532 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][N:4]=1.[P:13]([O:20]CC)([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16]>C1(C)C=CC=CC=1>[F:10][C:9]([F:12])([F:11])[C:6]1[CH:7]=[CH:8][C:3]([CH2:2][P:13](=[O:20])([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16])=[N:4][CH:5]=1

참가 물질

4

반응물 2

HCID 31215Triethyl phosphiteHCID 214410942-(Bromomethyl)-5-(trifluoromethyl)pyridine

생성물 1

HCID 118320757Diethyl ((5-(trifluoromethyl)pyridin-2-yl)methyl)phosphonate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 2-(bromomethyl)-5-(trifluoromethyl)pyridine (3.0 g, 12.5 mmol) in toluene (100 ml) was added triethyl phosphite (6.2 g, 37.0 mmol). The reaction was refluxed for 17 hours and was then concentrated in vacuo. The resulting residue was purified by column chromatography (silica, 0-50% ethyl acetate/n-hexane) to afford the title compound.

후처리

  1. temperatureThe reaction was refluxed for 17 hours
  2. concentrationwas then concentrated in vacuo
  3. customThe resulting residue was purified by column chromatography (silica, 0-50% ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-ba5d370e327647bba035c5a3262fedbe
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156829B2

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