Pyrazole → 2-Methoxy-6-(1H-pyrazol-1-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]benzamide
Reaction equation
[N:1]1([C:6]2[C:7]([C:12]([NH:14][C@H:15]3[CH2:19][CH2:18][CH2:17][C@@H:16]3[NH:20][C:21]3[CH:26]=[N:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][N:22]=3)=[O:13])=N[CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.BrC1C=CC=[C:53]([O:57][CH3:58])C=1C(N[C@H]1CCC[C@@H]1NC1C=NC(C(F)(F)F)=CN=1)=O.N1C=CC=N1>>[CH3:53][O:57][C:58]1[CH:9]=[CH:10][CH:11]=[C:6]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)[C:7]=1[C:12]([NH:14][C@H:15]1[CH2:19][CH2:18][CH2:17][C@@H:16]1[NH:20][C:21]1[CH:26]=[N:25][C:24]([C:27]([F:28])([F:30])[F:29])=[CH:23][N:22]=1)=[O:13]Participants
4
Reactant 3
Product 1
Procedure
Prepared according to the procedure for 3-(1H-pyrazol-1-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]pyridine-2-carboxamide (Example 43) from 2-bromo-6-methoxy-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]benzamide (Example 49; 100 mg, 0.218 mmol) and 1H-pyrazole (30 mg, 0.435 mmol) to afford the title compound.
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-c206ca8e722b43afa17c8731fa9ec75c
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09156829B2
Reaction notes
Loading…