反应详情

3,5-Dichloro-4-(2,2,2-trifluoroethoxy)aniline (1.60 g, 6.15 mmol) in THF (20 mL) was added isopentyl nitrite (2.94 g, 17.22 mmol) dropwise. The resulting solution was refluxed for 6 h and the solvent was removed under reduced pressure. The residue was purified by column chromatography over silica gel eluted with PE to provide 1,3-dichloro-2-(2,2,2-trifluoroethoxy)benzene as colorless oil.

1. temperatureThe resulting solution was refluxed for 6 h
2. customthe solvent was removed under reduced pressure
3. customThe residue was purified by column chromatography over silica gel
4. washeluted with PE