HCID 89655921, compound → Thieno[3,2-d]pyrimidine-7-carbaldehyde

HRID 1750878Notes

Reaction equation

HRID 1750878 reaction equation
[OH:1][CH2:2][C:3]1[C:7]2[N:8]=[CH:9][N:10]=[CH:11][C:6]=2[S:5][CH:4]=1>ClCCl.O=[Mn]=O>[N:8]1[C:7]2[C:3]([CH:2]=[O:1])=[CH:4][S:5][C:6]=2[CH:11]=[N:10][CH:9]=1

Participants

4

Reactant 1

HCID 89655921HCID 89655921, compound

Product 1

HCID 55274736Thieno[3,2-d]pyrimidine-7-carbaldehydeYield 31.2%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

7-hydroxymethyl-thieno[3,2-d]pyrimidine (250 mg, 1.56 mmol) was dissolved in dichloromethane (10 mL), added with MnO2 (1.36 g, 15.60 mmol), followed by stirring for 2 hours. The reaction mixture was filtered through a Celite pad under reduced pressure, and concentrated to obtain the title compound (80 mg, 30%).

Workup

  1. filtrationThe reaction mixture was filtered through a Celite pad under reduced pressure
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-efa5f07eb6cf48498bca6d465890d760
Source dataset
uspto-grants-2015_10
Patent number
US09156852B2

Reaction notes

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