反应详情

3-nitrodibenzofuran (30 g, 141 mmol) was stirred in 500 mL ethyl acetate and 3 g of 10% Pd/C were added to the slurry. Reaction mixture was hydrogenated for 30 minutes at 50 psi H2 pressure. Reaction mixture was filtered through a small Celite pad. Filtrate was concentrated under reduced pressure and performed silica gel column using 9:1 DCM/Hexanes as eluent. Final isolated amount was 14.5 g (56% yield).

1. customReaction mixture
2. customReaction mixture
3. filtrationwas filtered through a small Celite pad
4. concentrationFiltrate was concentrated under reduced pressure
5. customFinal isolated amount