反应详情

In a Parr hydrogenation bottle, 10% Pd/C (0.77 g, 0.724 mmol) was added and the bottle purged with nitrogen. Next 2-nitrodibenzo[b,d]furan (15 g, 44.3 mmol) in 180 mL of ethyl acetate was added and the mixture was hydrogenated on a Parr Hydrogenator until no more hydrogen is taken up by the solution. The catalyst was filtered off through Celite and washed with ethyl acetate. The filtrate was evaporated and pre-absorbed onto Celite. The Celite mixture was purified using a Varian 400 g column eluting with dichloromethane. 10.9 g of product was obtained.

1. customthe bottle purged with nitrogen
2. filtrationThe catalyst was filtered off through Celite
3. washwashed with ethyl acetate
4. customThe filtrate was evaporated
5. custompre-absorbed onto Celite
6. customThe Celite mixture was purified
7. washeluting with dichloromethane