Hydrochloric Acid → HCID 66652308, compound

HRID 1750944Notes

Reaction equation

HRID 1750944 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][N:10]2[C:14](=[O:15])[C:13]3([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[N:12]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:11]2)=[CH:7][CH:6]=1)=[O:4].Cl>O1CCOCC1>[O:15]=[C:14]1[C:13]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:12]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:11][N:10]1[CH2:9][C:8]1[CH:7]=[CH:6][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:35][CH:34]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66652268HCID 66652268, compound

Product 1

HCID 66652308HCID 66652308, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(4-(methoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.31 g, 0.65 mmol) was added 4M solution of HCl in dioxane (3 mL). After stirring at room temperature for 90 minutes, the reaction mixture was concentrated in vacuo to obtain methyl 4-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-fb07c7f80c894815a98fc332682c45b7
Source dataset
uspto-grants-2015_10
Patent number
US09156840B2

Reaction notes

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