Hydrochloric Acid → HCID 66652151, compound

HRID 1750965Notes

Reaction equation

HRID 1750965 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[N:5]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:4][N:3]1[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([O:34][CH2:35][C:36](=[O:43])[N:37]2[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]2)=[O:33])[CH:27]=1.Cl>O1CCOCC1>[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:5]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:4][N:3]1[CH2:25][C:26]1[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=1)[C:32]([O:34][CH2:35][C:36](=[O:43])[N:37]1[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]1)=[O:33]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046605HCID 58046605, compound

Product 1

HCID 66652151HCID 66652151, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-Butyl 4-oxo-3-(3-((2-oxo-2-(piperidin-1-yl)ethoxy)carbonyl)benzyl)-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.17 g, 0.29 mmol) was added 4M solution of HCl in dioxane (3 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 2-oxo-2-(piperidin-1-yl)ethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a862ac38461b4587a0c5303ba0d9829a
Source dataset
uspto-grants-2015_10
Patent number
US09156840B2

Reaction notes

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