Hydrochloric Acid → HCID 66652155, compound

HRID 1750987Notes

Reaction equation

HRID 1750987 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3([CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[C:11](=[O:25])[N:10]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([O:35][CH3:36])=[O:34])[CH:28]=3)[CH2:9]2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]3([CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[C:11](=[O:25])[N:10]([CH2:26][C:27]3[CH:28]=[C:29]([CH:30]=[CH:31][CH:32]=3)[C:33]([O:35][CH3:36])=[O:34])[CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046676HCID 58046676, compound

Product 1

HCID 66652155HCID 66652155, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 1-(4-fluorophenyl)-3-(3-(methoxycarbonyl)benzyl)-4-oxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.42 g, 0.84 mmol) was added 4M solution of HCl in dioxane (5 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain methyl 3-((1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-132002aaecaa4dbaac204f0da4b947bb
Source dataset
uspto-grants-2015_10
Patent number
US09156840B2

Reaction notes

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