反应详情

温度

78 °C

To a solution of tert-butyl 3-((1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate (0.2 g, 0.46 mmol), sodium iodide (0.021 g, 0.14 mmol) and potassium bicarbonate (0.069 g, 0.69 mmol) in 2-butanone (5 mL), was added 1-(3-chloropropyl)indolin-2-one (0.096 g, 0.46 mmol). After stirring at 78° C. for 2 hours, the reaction mixture was filtered and isolated by preparatory TLC (10% methanol/dichloromethane) to obtain tert-butyl 3-((1-(4-fluorophenyl)-4-oxo-8-(3-(2-oxoindolin-1-yl)propyl)-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate (0.075 g, 27%).

1. filtrationthe reaction mixture was filtered
2. customisolated by preparatory TLC (10% methanol/dichloromethane)