Hydrochloric Acid → HCID 131731301, compound

HRID 1751135Notes

Reaction equation

HRID 1751135 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:36]=[CH:35][C:9]([CH2:10][N:11]2[C:15](=[O:16])[C:14]3([CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)[N:13]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:12]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[ClH:37]>O1CCOCC1>[ClH:37].[O:16]=[C:15]1[C:14]2([CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[N:13]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:12][N:11]1[CH2:10][C:9]1[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:36][CH:35]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046704HCID 58046704, compound

Product 1

HCID 131731301HCID 131731301, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 3-(4-(methylsulfonamido)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (2.30 g, 4.47 mmol) and 4M hydrochloric acid in 1,4-dioxane (25 mL) were stirred at room temperature for 2 hours. The reaction was evaporated and dried under vacuum to give product as a light yellow solid (2.02 g, quant.); MS for C21H26N4O3S m/z 415 (M+H)+.

Workup

  1. customThe reaction was evaporated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-3dec77540caf4a09a73066a25c7be02c
Source dataset
uspto-grants-2015_10
Patent number
US09156840B2

Reaction notes

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