Nitric Acid → HCID 131733612, compound

HRID 1751166Notes

Reaction equation

HRID 1751166 reaction equation
[OH-].[Na+].[C:3]([O:9]CC)(=[O:8])[CH2:4][C:5]([CH3:7])=[O:6].[N+]([O-])(O)=[O:13].[N+]([O-])([O-])=O.[Cu+2:20].[N+]([O-])([O-])=O>>[OH2:6].[OH2:13].[C:3]([O-:9])(=[O:8])[CH2:4][C:5]([CH3:7])=[O:6].[Cu+2:20].[C:3]([O-:9])(=[O:8])[CH2:4][C:5]([CH3:7])=[O:6]

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 8868Ethyl AcetoacetateHCID 14798Sodium HydroxideHCID 18616Cupric nitrate

Product 1

HCID 131733612HCID 131733612, compound

Conditions

Temperature
30 °C

Procedure

Into a NaOH aqueous solution (2.30 g, 24.0 mL) for hydrolysis, 6.24 g (48.0 mmol) of ethyl acetoacetate was added, and stirred under heating at 30° C. for 3 hours. After the three hours, the reaction mixture was cooled down to 0° C., and a 5 N HNO3 aqueous solution was added thereto to make the reaction liquid acidic. To the reaction mixture, 2.90 g (4.80 mmol) of a copper (II) nitrate aqueous solution was added dropwise, and subjected to magnetic stirring for 4 hours. The precipitated solid was taken out by filtration, and washed with ion-exchanged water and acetone to obtain 2.05 g (6.70 mmol) of copper (II) acetoacetate dihydrate in the form of light blue solid.

Workup

  1. additionwas added
  2. temperatureAfter the three hours, the reaction mixture was cooled down to 0° C.
  3. customthe reaction liquid acidic
  4. stirringto magnetic stirring for 4 hours
  5. filtrationThe precipitated solid was taken out by filtration
  6. washwashed with ion-exchanged water and acetone

Sources & evidence

ORD record
ord-4dea63dd68a94a34b9a19432be8e97b1
Source dataset
uspto-grants-2015_10
Patent number
US09157004B2

Reaction notes

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