Tetrahydrofuran → 2-Benzyloxy-1-[6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-ethanol
Reaction equation
[Br:16][c:17]1[cH:18][c:19]([Cl:36])[c:20]([NH:23][c:24]2[c:25]([CH:34]=[O:35])[cH:26][c:27]3[c:28]([n:29][cH:30][nH:31]3)[c:32]2[F:33])[cH:21][cH:22]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][Li:10].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:11][CH2:12][CH2:13][CH2:14][Li:15]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH:34]([c:25]1[c:24]([NH:23][c:20]2[c:19]([Cl:36])[cH:18][c:17]([Br:16])[cH:22][cH:21]2)[c:32]([F:33])[c:28]2[c:27]([cH:26]1)[nH:31][cH:30][n:29]2)[OH:35]Participants
5
Sources & evidence
- ORD record
- ord-827cdf22fbe0464dbdc5745ccfb5e202
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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