Morpholine → HCID 86612009, compound

HRID 1751311Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[O:7]1[CH:9]([CH2:10][C:11]([F:23])([F:22])[C:12]([F:21])([F:20])[C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH2:8]1>>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][CH:9]([OH:7])[CH2:10][C:11]([F:22])([F:23])[C:12]([F:20])([F:21])[C:13]([F:18])([F:19])[C:14]([F:15])([F:17])[F:16])[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 27758192-(2,2,3,3,4,4,5,5,5-Nonafluoropentyl)oxirane

Product 1

HCID 86612009HCID 86612009, compoundYield 93.2%

Conditions

Temperature: 80 °C

Procedure

To 8.7 g of morpholine, 27.6 g of 1,2-epoxy-4,4,5,5,6,6,7,7,7-nonafluoroheptane was added dropwise. The mixture was then stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography, obtaining 33.8 g of 1-morpholino-4,4,5,5,6,6,7,7,7-nonafluoro-2-heptanol (yield 93%).

Workup

customThe reaction mixture was directly purified by silica gel column chromatography

Sources & evidence

ORD record: ord-091d4c43dc574be09355a5fdfcb87eb9
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09158191B2

Reaction notes

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