2-Morpholinoethanol → HCID 86612011, compound

HRID 1751313Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1.[O:10]1[CH:12]([CH2:13][C:14]([F:26])([F:25])[C:15]([F:24])([F:23])[C:16]([F:22])([F:21])[C:17]([F:20])([F:19])[F:18])[CH2:11]1>>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][CH2:11][CH:12]([OH:10])[CH2:13][C:14]([F:25])([F:26])[C:15]([F:23])([F:24])[C:16]([F:21])([F:22])[C:17]([F:18])([F:20])[F:19])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 611632-Morpholinoethanol

HCID 27758192-(2,2,3,3,4,4,5,5,5-Nonafluoropentyl)oxirane

Product 1

HCID 86612011HCID 86612011, compoundYield 73%

Conditions

Temperature: 80 °C

Procedure

A mixture of 13.1 g of 2-morpholinoethanol and 27.6 g of 1,2-epoxy-4,4,5,5,6,6,7,7,7-nonafluoroheptane was stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography. There was obtained 29.7 g of 1-(2-morpholinoethoxy)-4,4,5,5,6,6,7,7,7-nonafluoro-2-heptanol (yield 73%).

Workup

customThe reaction mixture was directly purified by silica gel column chromatography

Sources & evidence

ORD record: ord-0c13854b48a64d7192714c93eaee8b3f
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09158191B2

Reaction notes

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