反应详情

温度

80 °C

To a solution of (2S,3R)-methyl-3-(difluoromethoxy)-2-(methoxycarbonylamino)butanoate (265 mg, 1.1 mmol) in dichloroethane (10 mL) was added trimethyltin hydroxide (1 g, 5.5 mmol) and the resulting mixture was heated to 80° C. for 1 hour. The reaction was cooled to room temperature, diluted with ethyl acetate, washed twice with 5% aqueous HCl solution and brine, dried (MgSO4) and concentrated. The resulting crude material (209 mg, 84%) was used without further purification.

1. temperatureThe reaction was cooled to room temperature
2. washwashed twice with 5% aqueous HCl solution and brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. customThe resulting crude material (209 mg, 84%) was used without further purification