1-(4-Bromophenyl)-2-chloroethan-1-one → HCID 67682186, compound

HRID 1751480Notes

Reaction equation

HRID 1751480 reaction equation
COC(=O)NC(C1CCOCC1)C(N1C(C2NC(C3C=CC([C:25]4[CH:34]=[CH:33][C:32]5[C:27](=[CH:28][CH:29]=[C:30]([C:35]6[NH:36][C:37]([CH:40]7[CH2:44][CH2:43][CH2:42][N:41]7[C:45](=[O:58])[CH:46]([NH:53][C:54]([O:56][CH3:57])=[O:55])[C:47]7[CH:52]=CC=C[CH:48]=7)=[N:38][CH:39]=6)[CH:31]=5)[CH:26]=4)=CC=3)=CN=2)C2CC1CC2)=O.Br[C:68]1[CH:73]=CC(C(=O)CCl)=C[CH:69]=1.C(O[C:83]([N:85]1[CH2:89][CH2:88][CH2:87][CH:86]1[C:90](O)=O)=[O:84])(C)(C)C.[C:93]([O:97][C:98]([N:100]1[CH:105](C(O)=O)[CH:104]2[CH2:109]C1C[CH2:103]2)=[O:99])(C)(C)C.COC([NH:114][C@@H:115]([CH:119]([CH3:121])[CH3:120])[C:116](O)=O)=O.COC([NH:126]C(C1CCOCC1)C(O)=O)=O>>[CH3:93][O:97][C:98]([NH:100][C@@H:105]([CH:104]([CH3:103])[CH3:109])[C:83]([N:85]1[CH2:89][CH2:88][CH2:87][C@H:86]1[C:90]1[NH:114][C:115]([C:119]2[CH:121]=[C:69]([C:25]3[CH:26]=[C:27]4[C:32](=[CH:33][CH:34]=3)[CH:31]=[C:30]([C:35]3[NH:36][C:37]([C@@H:40]5[CH2:44][CH2:43][CH2:42][N:41]5[C:45](=[O:58])[C@@H:46]([NH:53][C:54](=[O:55])[O:56][CH3:57])[CH:47]([CH3:52])[CH3:48])=[N:38][CH:39]=3)[CH:29]=[CH:28]4)[CH:68]=[CH:73][CH:120]=2)=[CH:116][N:126]=1)=[O:84])=[O:99]

Participants

7

Reactant 6

HCID 778821-(4-Bromophenyl)-2-chloroethan-1-oneHCID 2684721-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acidHCID 10942966(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acidHCID 150563882-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acidHCID 585162412-(methoxycarbonylamino)-2-(tetrahydro-2H-pyran-4-yl)acetic acidHCID 69675356HCID 69675356, compound

Product 1

HCID 67682186HCID 67682186, compound

Procedure

The title compound was prepared as described for [2-(3-{5-[4-(6-{2-[1-(2-Methoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-phenyl]-1H-imidazol-2-yl}-2-aza-bicyclo[2.2.1]hept-2-yl)-2-oxo-1-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid methyl ester, substituting 2-bromo-1-(3-bromophenyl)ethanone for 1-(4-Bromo-phenyl)-2-chloro-ethanone, Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester for 2-Aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester, and (S)-2-(methoxycarbonylamino)-3-methylbutanoic acid for Methoxycarbonylamino-(tetrahydro-pyran-4-yl)-acetic acid.

Sources & evidence

ORD record
ord-f0b7fd9eca7f4ea69101144c5a2e0cba
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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