HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Bromophenyl)-2-chloroethan-1-one → HCID 67682186, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Bromophenyl)-2-chloroethan-1-one | HCID 77882 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| Reactant | (2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acid | HCID 10942966 | — |
| Reactant | 2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid | HCID 15056388 | — |
| Reactant | 2-(methoxycarbonylamino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid | HCID 58516241 | — |
| Reactant | HCID 69675356 | HCID 69675356 | — |
| Product | HCID 67682186 | HCID 67682186 | — |
Reaction Steps
The title compound was prepared as described for [2-(3-{5-[4-(6-{2-[1-(2-Methoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-phenyl]-1H-imidazol-2-yl}-2-aza-bicyclo[2.2.1]hept-2-yl)-2-oxo-1-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid methyl ester, substituting 2-bromo-1-(3-bromophenyl)ethanone for 1-(4-Bromo-phenyl)-2-chloro-ethanone, Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester for 2-Aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester, and (S)-2-(methoxycarbonylamino)-3-methylbutanoic acid for Methoxycarbonylamino-(tetrahydro-pyran-4-yl)-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156823B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-f0b7fd9eca7f4ea69101144c5a2e0cba |
| Source note | uspto-grants-2015_10 |