Dichloromethane → 4-[2-(Cyclopropanecarbonyl-amino)-2-phenyl-acetyl]-morpholine-3-carboxylic acid {4-[3-(5-chloro-2-hydroxy-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenyl}-amide
Reaction equation
[CH:48]([N:49]=[C:50]=[N:51][CH:52]([CH3:53])[CH3:54])([CH3:55])[CH3:56].[Cl:1][c:2]1[cH:3][cH:4][c:5]([OH:41])[c:6](-[c:8]2[n:9][n:10]([CH3:40])[cH:11][c:12]2[C:13]#[C:14][c:15]2[cH:16][cH:17][c:18]([NH:21][C:22](=[O:23])[CH:24]3[CH2:25][O:26][CH2:27][CH2:28][N:29]3[C:30]([CH:31]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[NH2:38])=[O:39])[cH:19][cH:20]2)[cH:7]1.[Cl:57][CH2:58][Cl:59].[OH:42][C:43](=[O:44])[CH:45]1[CH2:46][CH2:47]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([OH:41])[c:6](-[c:8]2[n:9][n:10]([CH3:40])[cH:11][c:12]2[C:13]#[C:14][c:15]2[cH:16][cH:17][c:18]([NH:21][C:22](=[O:23])[CH:24]3[CH2:25][O:26][CH2:27][CH2:28][N:29]3[C:30]([CH:31]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[NH:38][C:43](=[O:42])[CH:45]3[CH2:46][CH2:47]3)=[O:39])[cH:19][cH:20]2)[cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-7340456e618d48729794ba15354b05ea
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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