反应详情

温度

110 °C

A mixture of 1-(5-bromo-2-iodobenzyloxy)-6-methoxynaphthalene (5.0 g, 10.7 mmol) and sodium acetate (2.64 g, 32.1 mmol) in dimethylformamide (100 mL) was degassed with a stream of argon for 15 minutes. PdCl2(PPh3)2 was added and the reaction was heated to 110° C. After 16 hours the reaction was diluted with ethyl acetate, washed with water and brine, dried (Na2SO4) and concentrated. The resulting residue was purified by flash column chromatography to yield 8-bromo-2-methoxy-6H-dibenzo[c,h]chromene (1.29 g, 35%).

1. customwas degassed with a stream of argon for 15 minutes
2. additionPdCl2(PPh3)2 was added
3. additionAfter 16 hours the reaction was diluted with ethyl acetate
4. washwashed with water and brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customThe resulting residue was purified by flash column chromatography