Acetyl chloride → 2-Acetoxy-2-(3-bromophenyl)acetic acid

HRID 1751770Notes

Reaction equation

HRID 1751770 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Br:5][C:6]1[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=1)[CH:9]([OH:13])[C:10]([OH:12])=[O:11]>>[C:1]([O:13][CH:9]([C:8]1[CH:14]=[CH:15][CH:16]=[C:6]([Br:5])[CH:7]=1)[C:10]([OH:12])=[O:11])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 27570282-(3-Bromophenyl)-2-hydroxyacetic acid

Product 1

HCID 712121582-Acetoxy-2-(3-bromophenyl)acetic acid

Procedure

Acetyl Chloride (1.5 mL) was added to 3-bromomandelic acid 1 (1.00 g, 4.33 mmol) and stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo to provide compound 2 which was used in the next reaction without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-012dce4163504b78a7ad063b78e6b549
Source dataset
uspto-grants-2015_10
Patent number
US09161924B2

Reaction notes

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