Hydrochloric Acid → HCID 21487875, compound

HRID 1751781Notes

Reaction equation

HRID 1751781 reaction equation
C(Cl)[Cl:2].[F:4][C:5]([F:23])([F:22])[C:6]([NH:8][CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)=[O:7].Cl>O1CCOCC1>[ClH:2].[F:23][C:5]([F:4])([F:22])[C:6]([NH:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 21993671HCID 21993671, compound

Product 1

HCID 21487875HCID 21487875, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a stirred DCM solution of the title compound of Example 1 (100 mL) was added dropwise a solution of hydrogen chloride (250 mL, 1.0 mol) in 1,4-dioxane (4 M). Stirring was continued for 6 hours, then the suspension was filtered, and the solid washed with diethyl ether (500 mL) to afford the title compound (54.2 g, 96% yield) as a white solid. APCI/MS calcd. for C7H11F3N2O 196.1. found m/z=196.9 (M+1).

Workup

  1. filtrationthe suspension was filtered
  2. washthe solid washed with diethyl ether (500 mL)

Sources & evidence

ORD record
ord-ab841e8b50324beb877a700e04960347
Source dataset
uspto-grants-2015_10
Patent number
US09161948B2

Reaction notes

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