反应详情

温度

120 °C

1.4 g 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (II) are placed in 9 ml dioxane, then 3.5 ml diisopropylethylamine are added followed by 0.9 g D-norvalinol. The reaction mixture is heated in the microwave at 120° C. until there is no further reaction then cooled and evaporated down. The residue is treated with petroleum ether/ethyl acetate 9:1 in the ultrasound bath, the solid is suction filtered and dried. 1.5 g (III-3) are obtained in the form of a solid. 1H NMR (400 MHz, DMSO): 4.67 (1H, t); 0.86 (3H, t).

1. customno further reaction
2. temperaturethen cooled
3. customevaporated down
4. additionThe residue is treated with petroleum ether/ethyl acetate 9:1 in the ultrasound bath
5. filtrationfiltered
6. customdried
7. custom1.5 g (III-3) are obtained in the form of a solid