(S)-5-dibenzylamino-1-methylpiperidin-2-one → HCID 28064098, compound

HRID 1751791Notes

Reaction equation

HRID 1751791 reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 59708472(S)-5-dibenzylamino-1-methylpiperidin-2-one

Product 1

HCID 28064098HCID 28064098, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.450 g (S)-5-dibenzylamino-1-methylpiperidin-2-one are suspended in 25 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and at a temperature of 60° C. After 16 hours the catalyst is removed by suction filtering and the filtrate is evaporated to dryness. 0.190 g of the product are obtained in the form of an oil. 1H NMR (400 MHz, DMSO): 2.76 (3H, s).

Workup

  1. customAfter 16 hours the catalyst is removed by suction
  2. filtrationfiltering
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-5572e900498a42d38ec423e30f0d8dcb
Source dataset
uspto-grants-2015_10
Patent number
US09161927B2

Reaction notes

Loading…