Diisopropylethylamine → HCID 58080356, compound

HRID 1751801Notes

Reaction equation

HRID 1751801 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2[N:7]=1.C(N(C(C)C)CC)(C)C.[NH2:21][C:22]1([C:25]([OH:28])([CH3:27])[CH3:26])[CH2:24][CH2:23]1>O1CCOCC1>[Cl:1][C:2]1[N:3]=[C:4]([NH:21][C:22]2([C:25]([OH:28])([CH3:27])[CH3:26])[CH2:24][CH2:23]2)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 12433335HCID 12433335, compoundHCID 457899672,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Product 1

HCID 58080356HCID 58080356, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
160 °C

Procedure

2.7 g (II) are placed in 30 ml dioxane, then 6.8 ml diisopropyl-ethylamine and 1.8 g 2-(1-aminocyclopropyl)-propan-2-ol (cf. Liebigs Ann. Chem. 1978.1194) are added. The reaction mixture is heated to 160° C. until there is no further reaction and after cooling it is evaporated to dryness. The residue is mixed with ice water. The product is extracted with dichloromethane and purified by chromatography. 125 mg (III-8) are obtained in the form of a solid. Analytical HPLC-MS (method A): RT=1.08 min.

Workup

  1. customno further reaction
  2. temperatureafter cooling it
  3. customis evaporated to dryness
  4. additionThe residue is mixed with ice water
  5. extractionThe product is extracted with dichloromethane
  6. custompurified by chromatography
  7. custom125 mg (III-8) are obtained in the form of a solid

Sources & evidence

ORD record
ord-6dcb647e1595450388ac3a93c09d6baa
Source dataset
uspto-grants-2015_10
Patent number
US09161927B2

Reaction notes

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