HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 58080349, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate | HCID 22405349 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58080349 | HCID 58080349 | — |
Reaction Steps
500 mg tert-butyl 4-(1H-indol-3-yl)-piperidine-1-carboxylate are placed in 8 ml dimethylformamide and 73.3 mg sodium hydride (60% in mineral oil) are added. After 15 min 175 μl methyl iodide are added. The reaction mixture is stirred at ambient temperature. After the reaction is complete the product is purified directly by preparative HPLC (method C). 302 mg of the product are obtained in the form of an oil. Analytical HPLC-MS (method A): RT=1.65 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09161927B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-8668ac42d52e4ddc811cb8a230409b5f |
| Source note | uspto-grants-2015_10 |