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HRID1751802

反应详情

EQUATION

反应方程式

HRID 1751802 的结构方程式

REACTANTS

反应物

3
结构：CI
HCID6328

Methyl iodide

CH3I

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(C)(C)OC(=O)N1CCC(c2c[nH]c3ccccc23)CC1
HCID22405349

tert-Butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

C18H24N2O2

PRODUCTS

生成物

1
结构：Cn1cc(C2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc21
HCID58080349

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

500 mg tert-butyl 4-(1H-indol-3-yl)-piperidine-1-carboxylate are placed in 8 ml dimethylformamide and 73.3 mg sodium hydride (60% in mineral oil) are added. After 15 min 175 μl methyl iodide are added. The reaction mixture is stirred at ambient temperature. After the reaction is complete the product is purified directly by preparative HPLC (method C). 302 mg of the product are obtained in the form of an oil. Analytical HPLC-MS (method A): RT=1.65 min.

WORKUP

后处理

  1. customis purified directly by preparative HPLC (method C)