β-amino-α-phenyl-Benzeneethanol → HCID 58080370, compound

HRID 1751808Notes

Reaction equation

HRID 1751808 reaction equation
[N:1]1([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5][CH:4]([C:7]([O-:9])=O)[CH2:3][CH2:2]1.[NH2:17][CH:18]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)O>>[C:27]1([C:18]2[N:17]=[C:7]([CH:4]3[CH2:3][CH2:2][N:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]3)[O:9][C:19]=2[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 22243β-amino-α-phenyl-BenzeneethanolHCID 6921829HCID 6921829, compound

Product 1

HCID 58080370HCID 58080370, compound

Procedure

Starting from 1.08 g of mono-tert-butyl piperidine-1,4-dicarboxylate and 1 g 2-amino-1,2-diphenyl-ethanol the product may be prepared as described in the literature (cf. Tet. 2001, 4867). The product is purified by chromatography (method B). 560 mg are obtained in the form of an oil. Analytical HPLC-MS (method A): RT=1.72 min.

Workup

  1. custommay be prepared
  2. customThe product is purified by chromatography (method B)
  3. custom560 mg are obtained in the form of an oil

Sources & evidence

ORD record
ord-4d5a96054dfc41b4ab538d5659f3bea7
Source dataset
uspto-grants-2015_10
Patent number
US09161927B2

Reaction notes

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