Trifluoroacetic acid → HCID 58080362, compound

HRID 1751809Notes

Reaction equation

HRID 1751809 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58080370HCID 58080370, compound

Product 1

HCID 58080362HCID 58080362, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

560 mg tert-butyl 4-(4,5-diphenyloxazol-2-yl)-piperidine-1-carboxylate are placed in 2 ml dichloromethane, then 1.1 ml trifluoroacetic acid are added. The reaction mixture is stirred for 15 hours at ambient temperature, then evaporated to dryness. The residue is combined with toluene and evaporated to dryness again. The residue is mixed with diethyl ether and the precipitated solid is suction filtered and dried. 510 mg (V-10) are obtained. Analytical HPLC-MS (method B): RT=1.38 min.

Workup

  1. customevaporated to dryness
  2. customevaporated to dryness again
  3. additionThe residue is mixed with diethyl ether
  4. filtrationfiltered
  5. customdried
  6. custom510 mg (V-10) are obtained

Sources & evidence

ORD record
ord-79fae8eb3f28415488dcd2d91183aa19
Source dataset
uspto-grants-2015_10
Patent number
US09161927B2

Reaction notes

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