Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → 4-(2-Hydroxy-2-(4-tert-butylphenyl)ethoxy)quinazoline

Participants

Reaction Conditions

Reaction Steps

4-(2-tetrahyropyranyloxy-2-(4-tert-butylphenyl)ethoxy) quinazoline (0.25 g, 0.615 mmol) is dissolved in 5 ml ethanol and pyridinium-p-toluenesulfonate (15.4 mg, 0.061 mmol) is added to it. The solution is heated to 55° C. and stirred at that temperature for 4 hours. The ethanol is removed and the crude is purified by flash chromatography (silica gel; ethyl acetate/hexanes).

Provenance & Evidence