反应详情

温度

55 °C

4-(2-tetrahyropyranyloxy-2-(4-tert-butylphenyl)ethoxy) quinazoline (0.25 g, 0.615 mmol) is dissolved in 5 ml ethanol and pyridinium-p-toluenesulfonate (15.4 mg, 0.061 mmol) is added to it. The solution is heated to 55° C. and stirred at that temperature for 4 hours. The ethanol is removed and the crude is purified by flash chromatography (silica gel; ethyl acetate/hexanes).

1. customThe ethanol is removed
2. customthe crude is purified by flash chromatography (silica gel; ethyl acetate/hexanes)