Pyrazole → HCID 57008674, compound

Participants

Reaction Steps

Following general procedure A (90° C., 30 hours), 1H-pyrazole (205 mg, 3.0 mmol) is coupled with 4-bromo-1,1′-biphenyl (446 mg, 2.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 410 mg (93% isolated yield) of the desired product as a white crystal.

Provenance & Evidence