Pyrazole → HCID 57008674, compound

HRID 1751920Notes

Reaction equation

HRID 1751920 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.Br[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][CH:8]=1>>[C:10]1([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:11]=[CH:12][C:7]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 71014-Bromobiphenyl

Product 1

HCID 57008674HCID 57008674, compound

Procedure

Following general procedure A (90° C., 30 hours), 1H-pyrazole (205 mg, 3.0 mmol) is coupled with 4-bromo-1,1′-biphenyl (446 mg, 2.0 mmol). The crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50) to provide 410 mg (93% isolated yield) of the desired product as a white crystal.

Workup

  1. customThe crude brown oil is purified by flash chromatography on silica gel (eluent: dichloromethane/hexanes=50/50)
  2. customto provide

Sources & evidence

ORD record
ord-4363b4f9634249249cea14093f4af34e
Source dataset
uspto-grants-2015_10
Patent number
US09162953B2

Reaction notes

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