Sodium Hydroxide → HCID 51355569, compound

HRID 1752002Notes

Reaction equation

HRID 1752002 reaction equation
[IH:1].Cl[C:3]1[CH:8]=[C:7]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[N:6]=[CH:5][N:4]=1.[OH-].[Na+]>>[I:1][C:3]1[CH:8]=[C:7]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[N:6]=[CH:5][N:4]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24841Hydrogen iodideHCID 249021114-Chloro-6-thiophen-2-yl-pyrimidine

Product 1

HCID 51355569HCID 51355569, compoundYield 94.1%

Procedure

Aqueous solution of HI (63.5 g, 496.5 mol, 13.9 equiv) was charged to 4-chloro-6-thiophen-2-yl-pyrimidine (3, 7.0 g, 35.6 mmol) and stirring was continued for 20 h. Reaction mixture was then made slightly alkaline (pH˜10) by using 5% NaOH solution. Subject compound was precipitated out, filtered, washed well with distilled water and dried under vacuum to yield 9.6 g of 4 (Yield=94.1%).

Workup

  1. customReaction mixture
  2. customSubject compound was precipitated out
  3. filtrationfiltered
  4. washwashed well with distilled water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-611d62135ad544cc92527b9db78ad7c6
Source dataset
uspto-grants-2015_10
Patent number
US09162987B2

Reaction notes

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