反应详情

To a solution of (E)-2-(2,6-dichlorobenzamido)-5-[4-(4-hydroxytetrahydropyran-4-yl)-phenyl]pent-4-enoic acid methyl ester (56 mg) in THF (1.76 ml), 0.1N aqueous sodium hydroxide solution (1.76 ml) was added, and the resulting mixture was stirred at room temperature for 2 hours. After washing the reaction solution with ether, aqueous layer was acidified by adding 1N hydrochloric acid thereto and extracted twice with ethyl acetate. Organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated to dryness to obtain (E)-2-(2,6-dichlorobenzamido)-5-[4-(4-hydroxytetrahydropyran-4-yl)-phenyl]pent-4-enoic acid (48 mg).

1. washAfter washing the reaction solution with ether, aqueous layer
2. additionby adding 1N hydrochloric acid
3. extractionextracted twice with ethyl acetate
4. washOrganic layers were washed with saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. customAfter removing anhydrous sodium sulfate
7. filtrationby filtration
8. concentrationthe filtrate was concentrated to dryness