N-Hydroxyphthalimide → HCID 21746216, compound

HRID 1752142Notes

Reaction equation

HRID 1752142 reaction equation
[OH:1][N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].[F:13][CH:14]([F:17])[CH2:15]O>>[F:13][CH:14]([F:17])[CH2:15][O:1][N:2]1[C:3](=[O:12])[C:4]2[C:5](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:7]

Participants

3

Reactant 2

HCID 10665N-HydroxyphthalimideHCID 1361872,2-Difluoroethan-1-ol

Product 1

HCID 21746216HCID 21746216, compoundYield 52%

Procedure

N-Hydroxyphthalimide and 2,2-difluoro-ethanol were reacted as described for compound LXI in Example 27, affording XCVIII in 52% yield. 400 MHz 1H NMR (DMSO-d6, ppm) 7.92-7.85 (4H, m), 6.34 (1H, tt, J=54.4, 3.9 Hz), 4.46 (2H, td, J=14.1, 3.9 Hz).

Workup

  1. customaffording XCVIII in 52% yield

Sources & evidence

ORD record
ord-2d2a0b1387fe4836aa2a7d081085c957
Source dataset
uspto-grants-2015_10
Patent number
US09162992B2

Reaction notes

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