Hydrochloric Acid → HCID 69812137, compound

HRID 1752294Notes

Reaction equation

HRID 1752294 reaction equation
[CH3:1][N:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C@H:13]3[CH2:17][CH2:16][CH2:15][N:14]3C(OC(C)(C)C)=O)[S:11][CH:12]=2)=[CH:4][C:3]1=[O:25].[ClH:26]>C(Cl)Cl.O1CCOCC1>[ClH:26].[CH3:1][N:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C@H:13]3[CH2:17][CH2:16][CH2:15][NH:14]3)[S:11][CH:12]=2)=[CH:4][C:3]1=[O:25]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67479922HCID 67479922, compound

Product 1

HCID 69812137HCID 69812137, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

(R)-tert-butyl 2-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)thiazol-2-yl)pyrrolidine-1-carboxylate (131 mg,) was dissolved in CH2Cl2 (5 mL) and 4 M HCl in dioxane (5 mL) was added. The mixture was stirred at rt for 3 h and concentrated to afford (R)-1-methyl-4-(2-(pyrrolidin-2-yl)thiazol-4-yl)pyridin-2(1H)-one HCl salt (127 mg) as an off-white solid. LC-MS Method 1 tR=0.40 min, m/z=262.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-c23042e11c004e54a0a38825e4ed6491
Source dataset
uspto-grants-2015_10
Patent number
US09163012B2

Reaction notes

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