1-Boc-4-(aminomethyl)piperidine → Tert-butyl 4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

HRID 1752518Notes

Reaction equation

HRID 1752518 reaction equation
COC1C=C2C(=CC=1)NN=C2C(NCC1CCN(CC2SC=C(C(OC)=O)N=2)CC1)=O.[Br:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][N:37]=[C:36]2[C:42]([OH:44])=O.[NH2:45][CH2:46][CH:47]1[CH2:52][CH2:51][N:50]([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[CH2:49][CH2:48]1>>[Br:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][N:37]=[C:36]2[C:42]([NH:45][CH2:46][CH:47]1[CH2:52][CH2:51][N:50]([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[CH2:49][CH2:48]1)=[O:44]

Participants

4

Reactant 3

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 71573585-bromo-1H-indazole-3-carboxylic AcidHCID 89767420HCID 89767420, compound

Product 1

HCID 89767452Tert-butyl 4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

Procedure

Tert-butyl 4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate 11a was prepared, according to the procedure described for compound 7, from 5-bromo-1H-indazole-3-carboxylic acid and tert-butyl 4-(aminomethyl)piperidine-1-carboxylate. Yield: 40.6 g, 87%

Sources & evidence

ORD record
ord-960c9831dbd24826ba6a92c0b1d4dcd7
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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