Hydrochloric Acid → HCID 89767022, compound

HRID 1752519Notes

Reaction equation

HRID 1752519 reaction equation
[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)=[O:13]>CCOCC.CO>[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1)=[O:13]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 89767452Tert-butyl 4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

Product 1

HCID 89767022HCID 89767022, compoundYield 76%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

2M HCl in Et2O (1.8 L) was added to a solution of compound tert-butyl 4-(aminomethyl)piperidine-1-carboxylate 11a (0.24 moles) in MeOH (500 mL). The mixture was stirred for 3 hours at room temperature then the resulting solid was filtered and dried to give 5-Bromo-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamide hydrochloride 11 b (76% yield).

Workup

  1. filtrationthe resulting solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-a61cb7650da5463db61b05f77772520b
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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