Dichloromethane → 1-[[4-[8-Chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]pyrrolidine-2-carbonyl]amino]-2-vinylcyclopropanecarboxylic acid ethyl ester
Reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([C:35]([NH:36][C:37]2([C:42](=[O:43])[O:44][CH2:45][CH3:46])[CH:38]([CH:40]=[CH2:41])[CH2:39]2)=[O:47])[CH2:10][CH:11]([O:13][c:14]2[cH:15][c:16](-[c:27]3[s:28][cH:29][c:30]([CH:32]([CH3:33])[CH3:34])[n:31]3)[n:17][c:18]3[c:19]([Cl:26])[c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:55][CH2:56][Cl:57].[OH:48][C:49]([C:50]([F:51])([F:52])[F:53])=[O:54]>>[NH:8]1[CH:9]([C:35]([NH:36][C:37]2([C:42](=[O:43])[O:44][CH2:45][CH3:46])[CH:38]([CH:40]=[CH2:41])[CH2:39]2)=[O:47])[CH2:10][CH:11]([O:13][c:14]2[cH:15][c:16](-[c:27]3[s:28][cH:29][c:30]([CH:32]([CH3:33])[CH3:34])[n:31]3)[n:17][c:18]3[c:19]([Cl:26])[c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-466d30a45c7747a0916bc6a120676395
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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