反应详情

To a suspension of 2-(chloromethyl)quinoline hydrochloride (10 g, 46.7 mmol) in EA/water (150 ml: 75 ml) was added sodium hydrogencarbonate powder portionwise until gas evolution ceased. The organic layer was collected, washed with brine (3×50 ml), dried over sodium sulfate and concentrated. The obtained crude title compound was used in without further purification (8 g, 96% yield).

1. customThe organic layer was collected
2. washwashed with brine (3×50 ml)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated