Morpholine → HCID 78210284, compound

HRID 1752605Notes

Reaction equation

HRID 1752605 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[C:13](=[O:14])[N:12]([CH3:15])[CH:11]=[C:10]2[C:16](=[O:32])[N:17]([CH2:20][CH2:21][C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=3)[C:18](=[O:19])[C:9]=12>CCO>[CH3:15][N:12]1[C:13](=[O:14])[C:8]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[C:9]2[C:18](=[O:19])[N:17]([CH2:20][CH2:21][C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=3)[C:16](=[O:32])[C:10]2=[CH:11]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 90421601HCID 90421601, compound

Product 1

HCID 78210284HCID 78210284, compoundYield 123%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Morpholine (0.355 ml, 4.08 mmol) was added to a solution of 7-chloro-5-methyl-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione (0.5 g, 1.36 mmol, see Example c1)) in EtOH (30 ml) and the reaction was stirred at 90° C. for 16 h. The solvent was removed to give the title compound (0.7 g, 123% yield), which was used in the next steps without further purification.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-65e14bbc0d944e79ae0a9ea66efdeaac
Source dataset
uspto-grants-2015_10
Patent number
US09163019B2

Reaction notes

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