Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | HCID 90421601 | HCID 90421601 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 78210284 | HCID 78210284 | 123% |
Reaction Steps
Morpholine (0.355 ml, 4.08 mmol) was added to a solution of 7-chloro-5-methyl-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione (0.5 g, 1.36 mmol, see Example c1)) in EtOH (30 ml) and the reaction was stirred at 90° C. for 16 h. The solvent was removed to give the title compound (0.7 g, 123% yield), which was used in the next steps without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09163019B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-65e14bbc0d944e79ae0a9ea66efdeaac |
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| Source note | uspto-grants-2015_10 |
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