2-(4-Fluorophenoxy)ethanol → 5,7-Diethyl-2-[2-(4-fluorophenoxy)ethoxy]-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 1752799Notes

Reaction equation

HRID 1752799 reaction equation
CS([C:5]1[N:17]=[C:8]2[N:9]=[C:10]([CH2:15][CH3:16])[CH:11]=[C:12]([CH2:13][CH3:14])[N:7]2[N:6]=1)(=O)=O.[F:18][C:19]1[CH:28]=[CH:27][C:22]([O:23][CH2:24][CH2:25][OH:26])=[CH:21][CH:20]=1>>[CH2:15]([C:10]1[CH:11]=[C:12]([CH2:13][CH3:14])[N:7]2[N:6]=[C:5]([O:26][CH2:25][CH2:24][O:23][C:22]3[CH:27]=[CH:28][C:19]([F:18])=[CH:20][CH:21]=3)[N:17]=[C:8]2[N:9]=1)[CH3:16]

Participants

3

Reactant 2

HCID 5743612-(4-Fluorophenoxy)ethanolHCID 867193202-Methanesulfonyl-5,7-diethyl-[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 766847955,7-Diethyl-2-[2-(4-fluorophenoxy)ethoxy]-[1,2,4]triazolo[1,5-a]pyrimidineYield 70%

Procedure

The title compound was prepared according to the experimentals described for Example 14 above from 2-methanesulfonyl-5,7-diethyl-[1,2,4]triazolo[1,5-a]pyrimidine and 2-(4-fluorophenoxy)ethan-1-ol in 70% yield. EM (calc.): 330.1; MS (ESI) m/e: 331.3 (M+H)+.

Sources & evidence

ORD record
ord-cc15693e6734439bb45be2e289715253
Source dataset
uspto-grants-2015_10
Patent number
US09163027B2

Reaction notes

Loading…