N-Phenyl diethanolamine → 2-{[2-({5,7-Diethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}oxy)ethyl](phenyl)amino}ethan-1-ol

HRID 1752801Notes

Reaction equation

HRID 1752801 reaction equation
CS([C:5]1[N:17]=[C:8]2[N:9]=[C:10]([CH2:15][CH3:16])[CH:11]=[C:12]([CH2:13][CH3:14])[N:7]2[N:6]=1)(=O)=O.[C:18]1([N:24]([CH2:28][CH2:29][OH:30])[CH2:25][CH2:26][OH:27])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:15]([C:10]1[CH:11]=[C:12]([CH2:13][CH3:14])[N:7]2[N:6]=[C:5]([O:27][CH2:26][CH2:25][N:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:28][CH2:29][OH:30])[N:17]=[C:8]2[N:9]=1)[CH3:16]

Participants

3

Reactant 2

HCID 8416N-Phenyl diethanolamineHCID 867193202-Methanesulfonyl-5,7-diethyl-[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 766847902-{[2-({5,7-Diethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}oxy)ethyl](phenyl)amino}ethan-1-olYield 43%

Procedure

The title compound was prepared according to the experimentals described for Example 14 above from 2-methanesulfonyl-5,7-diethyl-[1,2,4]-triazolo[1,5-a]pyrimidine and N-phenyldiethanolamine in 43% yield. EM (calc.): 355.2; MS (ESI) m/e: 356.3 (M+H)+.

Sources & evidence

ORD record
ord-ccc572f1ac0d472384f3381a855365a1
Source dataset
uspto-grants-2015_10
Patent number
US09163027B2

Reaction notes

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