2-Bromoethanol → HCID 8179216, compound

HRID 1752820Notes

Reaction equation

HRID 1752820 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([SH:12])[N:11]=[C:4]2[N:3]=1.Br[CH2:14][CH2:15][OH:16]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([S:12][CH2:14][CH2:15][OH:16])[N:11]=[C:4]2[N:3]=1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 178426287HCID 178426287, compound

Product 1

HCID 8179216HCID 8179216, compoundYield 84%

Procedure

The compound of the first step was prepared according to the experimentals described for Example 1 above from of 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol and 2-bromoethanol in 84% yield; EM (calc.): 224.1; MS (ESI) m/e: 225.0 (M+H)+. 1H NMR (DMSO-d6, 400 MHz) δ ppm: 7.09 (s, 1H), 5.05 (s, 1H), 3.70 (t, 2H), 3.30 (t, 2H), 2.66 (s, 3H), 2.54 (s, 3H).

Workup

  1. customThe compound of the first step was prepared

Sources & evidence

ORD record
ord-b59793fc503d419286ea5bce12674e94
Source dataset
uspto-grants-2015_10
Patent number
US09163027B2

Reaction notes

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