Formaldehyde → Methyl 2-(3-formyl-4-hydroxyphenyl)acetate

HRID 1752867Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.[CH2:13]=[O:14]>>[CH:13]([C:7]1[CH:6]=[C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:4]=[CH:3][C:2]=1[OH:1])=[O:14]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

Product 1

HCID 12374099Methyl 2-(3-formyl-4-hydroxyphenyl)acetateYield 100%

Procedure

Proceeding as in Reference 8, but substituting methyl 4-hydroxyphenylacetate (42.9 g, 0.258 mol) and paraformaldehyde (77.5 g, 2.58 mole), gave methyl 3-formyl-4-hydroxy-phenyl-acetate (50.0 g, ˜100%).

Sources & evidence

ORD record: ord-e96a151e715a415ba54eb937a0f76214
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09162986B2

Reaction notes

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