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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1752867Generated: October 28, 2026

Formaldehyde → Methyl 2-(3-formyl-4-hydroxyphenyl)acetate

https://huagongshe.com/reaction/1752867

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantBenzeneacetic acid, 4-hydroxy-, methyl esterHCID 518900—
ProductMethyl 2-(3-formyl-4-hydroxyphenyl)acetateHCID 12374099100%

Reaction Steps

Proceeding as in Reference 8, but substituting methyl 4-hydroxyphenylacetate (42.9 g, 0.258 mol) and paraformaldehyde (77.5 g, 2.58 mole), gave methyl 3-formyl-4-hydroxy-phenyl-acetate (50.0 g, ˜100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09162986B2
Source datasetuspto-grants-2015_10
ORD IDord-e96a151e715a415ba54eb937a0f76214
Source noteuspto-grants-2015_10