5-Fluoro-2-methoxyphenylboronic acid → 6-Benzyloxy-5'-fluoro-5-formyl-2'-methoxybiphenyl-3-carboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([CH:10]=[O:11])[C:7]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:6](Br)[CH:5]=1.[F:22][C:23]1[CH:24]=[CH:25][C:26]([O:32][CH3:33])=[C:27](B(O)O)[CH:28]=1>>[CH3:1][O:2][C:3]([C:4]1[CH:5]=[C:6]([C:25]2[CH:24]=[C:23]([F:22])[CH:28]=[CH:27][C:26]=2[O:32][CH3:33])[C:7]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([CH:10]=[O:11])[CH:9]=1)=[O:21]Participants
3
Procedure
Proceeding as in Reference 19, but substituting 4-benzyloxy-3-bromo-5-formyl-benzoic acid methyl ester (1.0 g, 2.71 mmol) and 5-fluoro-2-methoxyphenyl boronic acid (0.691 g, 4.16 mmol), gave 6-benzyloxy-5′-fluoro-5-formyl-2′-methoxybiphenyl-3-carboxylic acid methyl ester (0.620 g).
Sources & evidence
- ORD record
- ord-97eaf7026c0540ecb854f6b00ddde40c
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09162986B2
Reaction notes
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