HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-methoxyphenylboronic acid → 6-Benzyloxy-5'-fluoro-5-formyl-2'-methoxybiphenyl-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| Reactant | HCID 85975948 | HCID 85975948 | — |
| Product | 6-Benzyloxy-5'-fluoro-5-formyl-2'-methoxybiphenyl-3-carboxylic acid methyl ester | HCID 86607701 | 58% |
Reaction Steps
Proceeding as in Reference 19, but substituting 4-benzyloxy-3-bromo-5-formyl-benzoic acid methyl ester (1.0 g, 2.71 mmol) and 5-fluoro-2-methoxyphenyl boronic acid (0.691 g, 4.16 mmol), gave 6-benzyloxy-5′-fluoro-5-formyl-2′-methoxybiphenyl-3-carboxylic acid methyl ester (0.620 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162986B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-97eaf7026c0540ecb854f6b00ddde40c |
| Source note | uspto-grants-2015_10 |